Author

Sri Karthika Shanmugam

Columbia University Irving Medical CenterORCID 0000-0002-1467-401XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

Henry M. ColecraftiD· 2 shared Papiya Choudhury· 2 shared Robert S. KassiD· 2 shared Xinle ZouiD· 2 shared Arden Darko-BoatengiD· 1 shared Emmanuel AfriyieiD· 1 shared Enoch AmarhiD· 1 shared Francesca ValleseiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiophysics

Henry M. ColecraftORCID

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2 papers

Recent·Most cited

BiophysicsNature CommunicationsPeer-reviewedDec 6, 2025

Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies

Arden Darko-Boateng, Emmanuel Afriyie, Travis J. Morgenstern…·Henry M. Colecraft

This study demonstrates the use of divalent nanobodies to recruit NEDD4-2 E3 ligase to degrade ion channels, reducing their function with minimal off-target effects.

8 citations

humanproteomics

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Molecular BiologybioRxivPreprintSep 17, 2024

Decoding polyubiquitin regulation of KV7. 1 functional expression with engineered linkage-selective deubiquitinases

Sri Karthika Shanmugam, Scott A. Kanner, Xinle Zou…·Henry M. Colecraft

This study uses engineered deubiquitinases to investigate how different polyubiquitin linkages regulate KCNQ1 functional expression and trafficking, revealing distinct roles for each linkage type.

1 citation

humanproteomics

𝕏 PostBluesky