UHRF1 is critical for tumor-promoting inflammation and tumorigenesis in retinoblastoma
Yijun Gu, Marina Suarez-Pizarro, Claire C. Chen, Jie Wu, Loredana Zocchi, Susie Suh, Parker J. Smith, Sylvia M. Cruz, Roberto Tinoco, Claudia A. Benavente
This study shows that UHRF1 is essential for retinoblastoma progression by promoting oncogenic transcription, chromatin accessibility, and immune microenvironment shaping, but not tumor initiation.
bioRxiv · Mar 2, 2025 · PreprintCancer Biology