Claire C. Chen

This paper develops a miniaturized bioluminescent platform for imaging structured RNAs in live cells, achieving a 3-fold reduction in tag size compared to existing methods.

This study shows USP7 inhibition disrupts proteostasis and tumor growth in triple negative breast cancer by stabilizing E3 ubiquitin ligases and affecting DNA repair pathways.

This study shows that UHRF1 is essential for retinoblastoma progression by promoting oncogenic transcription, chromatin accessibility, and immune microenvironment shaping, but not tumor initiation.

The paper shows that inhibiting the CPEB3 ribozyme increases CPEB3 protein and enhances memory by promoting mRNA polyadenylation and translation.

This paper introduces a bioluminescent platform for tracking RNA in vivo, demonstrating single-copy detection and robust imaging in cells and live animals.

The paper shows that the CPEB3 ribozyme regulates hippocampal-dependent memory by modulating mRNA maturation and translation of plasticity-related genes.