Author

Pasi Soininen

University of Eastern Finland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Systems Biology· 2 Bioinformatics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 6 Organism:human· 5 Assay:metabolomics· 5 Research Focus:differential expression· 4 Research Focus:GWAS / association mapping· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Markus PerolaiD· 5 shared Antti J Kangas· 4 shared Mika Ala-Korpela· 4 shared Peter WürtziD· 4 shared Mika A. P. KähöneniD· 3 shared Mika TiaineniD· 3 shared Satu MännistöiD· 3 shared Terho Lehtimäki· 3 shared

Activity by Year

2015-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersGenomics

Markus PerolaORCID

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Author profile →

6 papers

Recent·Most cited

Metabolomic and genomic prediction of common diseases in 477,706 participants in three national biobanks

Nightingale Health Biobank Collaborative Group, Jeffrey C. Barrett, Tõnu Esko, Krista Fischer, Luke Jostins-Dean, Pekka Jousilahti, Heli Julkunen, Tuija Jääskeläinen, Nurlan Kerimov, Sini Kerminen, Anastassia Kolde, Harri T. Koskela, Jaanika Kronberg, Sara Lundgren, Annamari Lundqvist, , Peter Würtz

The paper develops metabolomic risk scores from half a million blood samples to predict 12 common diseases, showing they outperform polygenic scores and benefit from repeat measurements.

medRxiv · Jun 9, 2023 · PreprintGenetic & Genomic Medicine

An interaction map of circulating metabolites, immune gene networks and their genetic regulation

Artika P. Nath, Scott C. Ritchie, Sean Byars, Liam G. Fearnley, Aki Samuli Havulinna, Anni Joensuu, Antti J. Kangas, Pasi Soininen, Annika Wennerström, Lili A. Milani, Andres Metspalu, Satu Männistö, Peter Würtz, Johannes Kettunen, Emma Raitoharju, , Michael Inouye

The paper integrates transcriptomic, metabolomic, and genomic data to identify gene networks and their genetic regulation linked to immune function and circulating metabolites.

Genome biology · Aug 1, 2017Peer-reviewedGenomics

Metabolic signatures of birth weight in 18288 adolescents and adults

Peter Wurtz, Qin Wang, Marjo Niironen, Tuulia Tynkkynen, Mika Tiainen, Fotios Drenos, Antti J Kangas, Pasi Soininen, Michael Skilton, Kauko Heikkila, Anneli Pouta, Mika Kahonen, Terho Lehtimaki, Richard J Rose, Eero Kajantie, , Kirsi Auro

This study identifies metabolic signatures linked to birth weight in adolescents and adults, finding that lower birth weight is associated with adverse cardiometabolic biomarkers similar to higher BMI, but with weaker effects.

International Journal of Epidemiology · Nov 8, 2016Peer-reviewedSystems Biology

Metabolic profiling of alcohol consumption in 9778 young adults

Peter Würtz, Sarah Cook, Qin Wang, Mika Tiainen, Tuulia Tynkkynen, Antti J Kangas, Pasi Soininen, Jaana Laitinen, Jorma Viikari, Mika Kähönen, Terho Lehtimäki, Markus Perola, Stefan Blankenberg, Tanja Zeller, Satu Männistö, , David A Leon

This study examines the metabolic effects of alcohol consumption in young adults, finding associations with multiple cardiometabolic risk markers and a complex metabolic signature.

bioRxiv · Feb 29, 2016Systems Biology

metaCCA: Summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis

Anna Cichonska, Juho Rousu, Pekka Marttinen, Antti J Kangas, Pasi Soininen, Terho Lehtimäki, Olli T Raitakari, Marjo-Riitta Järvelin, Veikko Salomaa, Mika Ala-Korpela, Samuli Ripatti, Matti Pirinen

metaCCA performs multivariate meta-analysis of genome-wide association studies using canonical correlation analysis, showing agreement with pooled individual-level data.

Bioinformatics · Feb 19, 2016Peer-reviewedBioinformatics

Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

Scott C Ritchie, Peter Würtz, Artika P Nath, Gad Abraham, Aki S Havulinna, Antti J Kangas, Pasi Soininen, Kristiina Aalto, Ilkka Seppälä, Emma Raitoharju, Marko Salmi, Mikael Maksimow, Satu Männistö, Mika Kähönen, Markus Juonala, , Michael Inouye

This study links elevated glycoprotein acetyls (GlycA) to chronic inflammation and microbial infection risk using integrative omics and health records.

bioRxiv · Apr 28, 2015Genomics