Anastassia Kolde

Genome-wide association study for circulating metabolic traits in 619,372 individuals

This study performs a large-scale GWAS on 249 metabolic traits in 619,372 individuals, identifying 88,604 associations and using MR to explore causal links between metabolites and diseases.

Analysis of follow-up data in large biobank cohorts: a review of methodology

This paper reviews methodological challenges in GWAS of biobank data with time-to-event outcomes, proposing a two-step martingale residual approach for efficient analysis.

From Biobanking to Personalized Medicine: the journey of the Estonian Biobank

The paper reviews the Estonian Biobank's role in advancing genomics research and personalized medicine through its comprehensive data and translational focus.

Extensive co-regulation of neighbouring genes complicates the use of eQTLs in target gene prioritisation

The paper benchmarks methods for prioritizing GWAS target genes using eQTLs and finds that assigning pQTLs to closest protein-coding genes outperforms colocalisation methods.

Insights into the metabolic consequences of type 2 diabetes

This study identifies metabolites causally linked to type 2 diabetes and its complications, revealing genetic regulation effects and metabolic pathways involved.

Metabolomic and genomic prediction of common diseases in 477,706 participants in three national biobanks

The paper develops metabolomic risk scores from half a million blood samples to predict 12 common diseases, showing they outperform polygenic scores and benefit from repeat measurements.