Tanja Zeller

This study identifies C3aR signaling in ObRb-expressing neurons as a pathway contributing to leptin resistance and obesity-related cardiac remodeling, with potential therapeutic implications.

This study identifies ceramide-driven lipotoxicity as a driver of calcific aortic valve disease and shows that SPT inhibition can reverse disease progression in vivo.

The paper identifies uridine modifications in VSMCs linked to post-transcriptional regulation during atherogenic transitions using epitranscriptomic profiling.

The paper analyzes genetic variation in the LPA gene using short-read sequencing to predict LP(a) concentration, finding allele-specific KIV-2 CN provides better prediction than total CN.

This study identifies a latent clinical-anatomical dimension linking metabolic syndrome severity to brain morphology and cognition in 40,087 individuals.

This study compares WGS pipelines, finding DRAGEN outperforms GATK in speed and accuracy for variant calling and mapping.

This study integrates genomics, transcriptomics, and proteomics of human atrial tissue to identify regulatory variants and trans-acting networks associated with atrial fibrillation.

This paper introduces SAPPHO methods to detect pleiotropy in GWAS by modeling shared patterns of genetic associations, finding 16 additional and 124 novel loci in meta-analysis.

This study identifies 47 novel genetic loci associated with PR interval through genome-wide association meta-analysis across multiple populations.

This study examines the metabolic effects of alcohol consumption in young adults, finding associations with multiple cardiometabolic risk markers and a complex metabolic signature.