K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming
Maria Milanesi, Chiara Urbinati, Liv Zimmermann, Pasqua Oreste, Alberto Zani, Arnaldo Caruso, Francesca Caccuri, Vibor Laketa, Petr Chlanda, Rebecca C. Wade, Marco Rusnati, Giulia Paiardi
This study shows K5 polysaccharides inhibit SARS-CoV-2 by blocking spike binding to ACE2 and furin cleavage, with K5OSH showing stronger antiviral activity than heparin.
npj Viruses · Jan 9, 2026Peer-reviewedBiochemistry