Biochemistrynpj VirusesPeer-reviewed
K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming
Maria Milanesi, Chiara Urbinati, Liv Zimmermann…·Giulia Paiardi
This study shows K5 polysaccharides inhibit SARS-CoV-2 by blocking spike binding to ACE2 and furin cleavage, with K5OSH showing stronger antiviral activity than heparin.
DOI 10.1038/s44298-025-00163-4