TLR9 signaling requires ligand-induced phosphorylation of two specific tyrosine residues by EGFR and Syk
Manoj Veleeparambil, Chenyao Wang, Patricia Kessler, Pracheta Sengupta, Santanu Das, Ritu Chakravarti, Belinda B. Willard, Ganes C. Sen, Saurabh Chattopadhyay
This study identifies that TLR9 activation requires phosphorylation of two specific tyrosine residues by EGFR and Syk, which is critical for downstream signaling.
mBio · Sep 22, 2025Peer-reviewedImmunology