Author

Manoj Veleeparambil

Cleveland ClinicORCID 0000-0003-3545-5251Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Pracheta SenguptaiD· 2 shared Ritu ChakravartiiD· 2 shared Saurabh ChattopadhyayiD· 2 shared Belinda B. WillardiD· 1 shared Chenyao WangiD· 1 shared Ganes C. SeniD· 1 shared Karan ChawlaiD· 1 shared Patricia Kessler· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

Pracheta SenguptaORCID

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2 papers

Recent·Most cited

TLR9 signaling requires ligand-induced phosphorylation of two specific tyrosine residues by EGFR and Syk

Manoj Veleeparambil, Chenyao Wang, Patricia Kessler, Pracheta Sengupta, Santanu Das, Ritu Chakravarti, Belinda B. Willard, Ganes C. Sen, Saurabh Chattopadhyay

This study identifies that TLR9 activation requires phosphorylation of two specific tyrosine residues by EGFR and Syk, which is critical for downstream signaling.

mBio · Sep 22, 2025Peer-reviewedImmunology

A genetic screen to identify deubiquitinases as regulators of IRF7

Shumin Fan, Pracheta Sengupta, Karan Chawla, Manoj Veleeparambil, Ritu Chakravarti, Saurabh Chattopadhyay

The paper identifies USP2 and OTUD5 as deubiquitinases regulating IRF7 activity through distinct ubiquitination mechanisms, impacting antiviral immunity.

bioRxiv · Sep 9, 2025 · PreprintImmunology