Author

Patricia L. Dyal

University College London

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Neuroscience· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Christy HungiD· 1 shared David KlenermaniD· 1 shared Emre FertaniD· 1 shared Frederick J. LiveseyiD· 1 shared Rickie PataniiD· 1 shared Sarah DomoneyiD· 1 shared Sian GoldsworthyiD· 1 shared

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2025-2025 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Christy HungORCID

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1 paper

Recent·Most cited

Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytes

Sian Goldsworthy, Emre Fertan, Patricia L. Dyal, Sarah Domoney, Frederick J. Livesey, David Klenerman, Rickie Patani, Christy Hung

This study shows human astrocytes generate and release amyloid-β aggregates under lysosomal stress, contributing to extracellular Aβ accumulation in Alzheimer's disease.

bioRxiv · May 27, 2025 · PreprintNeuroscience