Vascular mimicry by VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development
Derek C. Sung, Xiaowen Chen, Mei Chen, Jisheng Yang, Susan Schultz, Apoorva Babu, Yitian Xu, Siqi Gao, TC Stevenson Keller, Patricia Mericko, Michelle Lee, Ying Yang, Joshua Paul Scallan, Mark L. Kahn
This study shows VE-cadherin is essential for trophoblast migration and spiral artery remodeling in mouse placental development, revealing a non-endothelial role for this protein in vascular mimicry.
eLife · Apr 29, 2022Peer-reviewedDevelopmental Biology