Author

Mark L. Kahn

University of PennsylvaniaORCID 0000-0002-6489-7086Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Derek C. SungiD· 2 shared Jisheng YangiD· 2 shared Siqi GaoiD· 2 shared Abhinav SrinathiD· 1 shared Aileen A. ReniD· 1 shared Apoorva Babu· 1 shared Chang CheniD· 1 shared Daniel A. SnellingsiD· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersDevelopmental Biology

Derek C. SungORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

YAP/TAZ signaling in allantois-derived cells is required for placental vascularization

Siqi Gao, Triloshan Thillaikumaran, Martin H. Dominguez, W. Giang, Kevin Hayes, Xiaowen Chen, Jesse A. Pace, Jenna Bockman, Danielle Jathan, Derek C. Sung, Sweta Narayan, Maxwell Frankfurter, Patricia Mericko-Ishizuka, Jisheng Yang, Marco Castro, , Mark L. Kahn

This study shows that YAP/TAZ signaling in allantois-derived cells is essential for placental vascularization, as its loss causes embryonic lethality and vascular defects.

bioRxiv · Sep 15, 2024 · PreprintDevelopmental Biology

Vascular mimicry by VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development

Derek C. Sung, Xiaowen Chen, Mei Chen, Jisheng Yang, Susan Schultz, Apoorva Babu, Yitian Xu, Siqi Gao, TC Stevenson Keller, Patricia Mericko, Michelle Lee, Ying Yang, Joshua Paul Scallan, Mark L. Kahn

This study shows VE-cadherin is essential for trophoblast migration and spiral artery remodeling in mouse placental development, revealing a non-endothelial role for this protein in vascular mimicry.

eLife · Apr 29, 2022Peer-reviewedDevelopmental Biology

Developmental Venous Anomalies are a Genetic Primer for Cerebral Cavernous Malformations

Daniel A. Snellings, Romuald Girard, Rhonda Lightle, Abhinav Srinath, Sharbel G. Romanos, Ying Li, Chang Chen, Aileen A. Ren, Mark L. Kahn, Issam A. Awad, Douglas A. Marchuk

The paper identifies PIK3CA mutations in developmental venous anomalies (DVA) and CCM, showing DVA act as a genetic primer for CCM through shared mutations.

Nature Cardiovascular Research · Mar 14, 2022Peer-reviewedGenetics