Siqi Gao

YAP/TAZ signaling in allantois-derived cells is required for placental vascularization

This study shows that YAP/TAZ signaling in allantois-derived cells is essential for placental vascularization, as its loss causes embryonic lethality and vascular defects.

Closely related type II-C Cas9 orthologs recognize diverse PAMs

The paper identifies type II-C Cas9 orthologs with diverse PAM recognition capabilities, enhancing allele-specific genome editing.

Vascular mimicry by VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development

This study shows VE-cadherin is essential for trophoblast migration and spiral artery remodeling in mouse placental development, revealing a non-endothelial role for this protein in vascular mimicry.

Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity

The paper identifies and engineers a compact SlugCas9 variant with broad targeting range, high specificity, and activity for genome editing.