Joshua Paul Scallan

Lymphatic Malformations with Activating KRAS Mutations Impair Lymphatic Valve Development Through Matrix Metalloproteinases

This study shows that KRAS mutations impair lymphatic valve development by upregulating MMPs, which degrade the valve ECM core.

A Gαq/11-IP3R1-ANO1 pacemaking axis underlies pressure-induced lymphatic chronotropy

This study identifies a Gαq/11-IP3R1-ANO1 signaling axis responsible for pressure-induced lymphatic contractions in mouse popliteal vessels.

Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function

This study identifies Zmiz1 as a regulator of lymphatic endothelial cell function and Prox1 expression, showing its role in lymphatic vessel development and valve formation.

Rictor induces AKT signaling to regulate lymphatic valve formation

This study shows that Rictor is essential for AKT signaling in lymphatic valve formation, as its deletion reduces valve numbers and impairs valve maturation.

Endothelial Nitric Oxide Synthase Regulates Lymphatic Valve Specification By Controlling β-catenin Signaling During Embryogenesis

This study shows eNOS regulates lymphatic valve specification by controlling β-catenin signaling during embryogenesis, independent of nitric oxide production.

Vascular mimicry by VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development

This study shows VE-cadherin is essential for trophoblast migration and spiral artery remodeling in mouse placental development, revealing a non-endothelial role for this protein in vascular mimicry.