Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury
Patricia Renz, Daniel Surbek, Valérie Haesler, Vera Tscherrig, Eric Jinsheng Huang, Manideep Chavali, Shane Antony Liddelow, David H. Rowitch, Andreina Schoeberlein, Amanda Brosius Lutz
This study shows that reducing C3-expressing reactive astrocytes in a mouse model of perinatal white matter injury improves myelination and behavioral outcomes, and identifies these cells as potential therapeutic targets in human WMI.
bioRxiv · Dec 19, 2022 · PreprintNeuroscience