Eric Jinsheng Huang

Specialized Shh-sensing cell with unique cilia and basal body in the forebrain ventricular epithelium

The paper identifies a novel ependymal cell type (E2) in the forebrain that senses cerebrospinal fluid signals via specialized cilia and Smoothened receptor.

A multimodal interrogation of Broca's area in the pediatric and adult human brain

The paper provides a high-resolution molecular and cellular analysis of Broca's area and motor cortex across developmental stages, identifying distinct cellular signatures and vulnerabilities to neurodevelopmental disorders.

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice

This study shows that transplanting wild-type human iPSC-derived microglia into progranulin-deficient mice reduces neuropathology, circuit dysfunction, and behavioral issues in a FTD model.

Spatial and Molecular Progression of Neural Progenitor Cells in the Developing Human Dentate Gyrus

This study maps the spatial and molecular changes in neural progenitor cells in the human dentate gyrus from gestation to postnatal stages, showing a decline in neurogenic potential and transition to astrocytic features.

Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier

This study uses proteomic profiling to identify age-related changes in transporter proteins in human brain microvessels, revealing alterations in BBB permeability and drug disposition.

CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism

This study generates CHCHD2 T61I mutant mice to model Parkinson's disease, finding mitochondrial dysfunction and metabolic shifts towards glycolysis.

Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1

The paper shows microglia regulate GABAergic neurogenesis in the prenatal human brain via IGF1, using single-cell transcriptomics and organoid models.

Loss of FMRP in microglia promotes degeneration of parvalbumin neurons and audiogenic seizures via progranulin insufficiency

This study shows that loss of FMRP in microglia reduces PV neuron density and causes audiogenic seizures by impairing lysosomal function and progranulin levels.

Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

This study maps the molecular and cellular dynamics of the developing human neocortex using single-nucleus data, revealing gene regulatory networks and a cancer-related progenitor subtype.

Substructure and maturation of lamina-associated domains in neurons of the developing and adult human brain

The paper investigates the substructure and maturation of lamina-associated domains (LADs) in postmitotic neurons across human brain development, revealing dynamic changes in T1 and T2 LADs.

Single-cell analysis of prenatal and postnatal human cortical development

The paper constructs a single-cell transcriptomic atlas of human cortical development, identifying lineage and sex-specific gene expression programs linked to autism risk.

A cross-species proteomic map reveals neoteny of human synapse development

This study creates a cross-species proteomic map of synapse development in human, macaque, and mouse neocortex, revealing slower human PSD maturation and its potential link to neoteny.

Granulin Loss of Function in Human Mature Brain Organoids Implicates Astrocytes in TDP-43 Pathology

The paper shows that loss of GRN in human brain organoids leads to TDP-43 pathology, driven by astrocytes, and can be rescued by progranulin.

Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

This study shows that reducing C3-expressing reactive astrocytes in a mouse model of perinatal white matter injury improves myelination and behavioral outcomes, and identifies these cells as potential therapeutic targets in human WMI.

Integrative single-cell characterization of hypothalamus sex-differential and obesity-associated genes and regulatory elements

The paper integrates single-cell RNA and ATAC-seq data from mouse and human hypothalamus to identify sex-specific genes and obesity-associated regulatory elements.

Developmental Dynamics of RNA Translation in the Human Brain

This study maps RNA translation dynamics in the human brain using ribosome profiling, identifying thousands of novel translation events and brain-specific microproteins linked to schizophrenia.

The autism-associated gene SYNGAP1 regulates human cortical neurogenesis

This study shows SYNGAP1, an autism risk gene, is expressed in human cortical progenitors and its dysfunction disrupts neurogenesis and cortical lamination.

Persistent postnatal migration of interneurons into the human entorhinal cortex

This study shows that interneurons continue to migrate into the human entorhinal cortex postnatally, with distinct lineage contributions and maturation patterns identified using single-nuclei RNAseq.

Molecular diversity and lineage commitment of human interneuron progenitors

The paper identifies molecular subtypes of human interneuron progenitors and immature interneurons using single-cell RNA sequencing and compares them to mouse data, revealing species-specific gene programs.

A developmental analysis of juxtavascular microglia dynamics and interactions with the vasculature

This paper analyzes juxtavascular microglia dynamics in mice and humans, showing their developmental migration along vessels and stabilization as astrocyte endfeet ensheath the vasculature.

Single-cell in situ transcriptomic map of astrocyte cortical layer diversity

The paper maps astrocyte layer diversity in the cortex using a high-content spatial transcriptomic pipeline, revealing distinct astrocyte identities and their relationship to neuronal organization.