BET inhibition induces HEXIM1- and RAD51-dependent conflicts between transcription and replication
Akhil Bowry, Ann Liza Piberger, Patricia Rojas, Marco Saponaro, Eva Petermann
This study shows BET inhibition causes replication stress through transcription-replication interference, involving HEXIM1 and RAD51, and reveals a new mechanism for BRD4's role in DNA replication and recombination.
Cell Reports · Nov 1, 2018Peer-reviewedMolecular Biology