PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts
Ann Liza Piberger, Akhil Bowry, Richard D. Kelly, Alexandra K. Walker, Daniel González‐Acosta, Laura J. Bailey, Aidan J. Doherty, Juan Méndez, Joanna R. Morris, Helen E. Bryant, Eva Petermann
This study shows that PrimPol creates single-stranded gaps at bulky DNA adducts, which recruit RAD51 for homologous recombination, facilitating DNA repair in mammalian cells.
Nature Communications · Nov 17, 2020Peer-reviewedMolecular Biology