Human APOE allelic variants suppress the formation of diffuse and fibrillar Aβ deposits relative to mouse Apoe in transgenic mouse models of Alzheimer amyloidosis
Guilian M. Xu, Patricia Sacilotto, Carmelina Gorski, Parul Bali, Susan Fromholt, Quan Vo, Karen N. McFarland, Qing Lu, David Borchelt, Paramita Chakrabarty
This study shows human APOE variants reduce both diffuse and fibrillar Aβ deposits in transgenic mouse models compared to mouse Apoe, with APOE3 more effective than APOE4 in some contexts.
bioRxiv · Apr 30, 2024 · PreprintNeuroscience