Seizures in a Dravet Syndrome mouse model inhibit the locus coeruleus but locally evoke supraphysiologic norepinephrine release
Meiling Zhao, Yiannos Demetriou, Anam Noor, Joseph Barden, Limei Zhu, Qianyi Yu, Alexander Sajdak, Arnav Akhaury, Chandni Rana, Peilin Yang, Yulong Li, Christian R. Burgess, Sam McKenzie, Paul Kramer, Joanna Mattis
The paper investigates NE release during seizures in a Dravet Syndrome mouse model, finding inhibited LC-NE neuron activity but increased NE release in downstream regions.
bioRxiv · Oct 1, 2026 · PreprintNeuroscience