Joanna Mattis

The paper investigates NE release during seizures in a Dravet Syndrome mouse model, finding inhibited LC-NE neuron activity but increased NE release in downstream regions.

The paper introduces a P-DOpE probe that combines optogenetics and electrophysiology for in vivo monitoring, showing it amplifies noradrenergic signaling in the hippocampus under specific conditions.

This study shows that hyperthermia reliably triggers seizures in a mouse model of focal cortical dysplasia, enabling testing of therapeutic interventions.

This study shows seizures impair REM sleep by disrupting cholinergic neurons in the pedunculopontine nucleus in a mouse model of Dravet Syndrome.

This study identifies impaired parvalbumin-expressing inhibitory neurons in the medial septum of Scn1a+/- mice, a model of Dravet Syndrome, suggesting a potential contribution to cognitive deficits.

This study shows that MCH projections to the nucleus accumbens enhance food reward value without inducing feeding or REM sleep, with sex differences observed.

This study identifies circuit dysfunction in the hippocampus of a Dravet syndrome mouse model and shows that restoring parvalbumin interneuron function can rescue circuit impairments.

This study identifies reciprocal GABAergic projections between the lateral hypothalamus and dorsal raphe nucleus that promote wakefulness through mutual inhibition and network activity modulation.