Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy
José L. McFaline‐Figueroa, Sanjay R Srivatsan, Andrew J. Hill, Molly J. Gasperini, Dana L. Jackson, Lauren M. Saunders, Silvia Domcke, Samuel G. Regalado, Paul Lazarchuck, Sarai Alvarez, Raymond J. Monnat, Jay Shendure, Cole Trapnell
The paper uses a combined single-cell genetic and chemical screening platform to analyze kinase dependencies in glioblastoma response to targeted therapy, identifying adaptive signaling and potential combination therapies.
Cell Genomics · Jan 25, 2024Peer-reviewedGenomics