To 200,000 m/z and beyond: native electron capture charge reduction mass spectrometry deconvolves heterogeneous signals in large biopharmaceutical analytes
Kyle I. P. Le Huray, Tobias P. Wörner, Tiago Moreira, Marcin Dembek, Maria Reinhardt-Szyba, Paul W. A. Devine, Nicholas J. Bond, Kyle L. Fort, Alexander Makarov, Frank Sobott
This paper demonstrates the use of electron-capture charge reduction (ECCR) to deconvolve heterogeneous signals in native mass spectrometry, achieving m/z values above 200,000 for large biopharmaceutical analytes.
ACS Central Science · Jul 26, 2024Peer-reviewedMolecular Biology