Frank Sobott

This study benchmarks sub-50 nm quartz nanopipette emitters for native electrospray ionization mass spectrometry across multiple platforms and protein sizes, showing improved signal-to-noise and reduced adduction.

This paper shows how ionic strength affects the structural disorder and oligomerization of the Phd transcription factor, revealing its ability to function as a conformational rheostat.

This study uses nanopipette electrospray ionisation ion mobility mass spectrometry to investigate how buffer conditions affect α-synuclein conformational dynamics.

This paper uses time-resolved cryoEM to directly observe the swinging lever mechanism of myosin-5, showing its structural changes during ATP hydrolysis and force generation.

This paper demonstrates the use of electron-capture charge reduction (ECCR) to deconvolve heterogeneous signals in native mass spectrometry, achieving m/z values above 200,000 for large biopharmaceutical analytes.

The paper investigates the effects of the E83Q mutation on alpha-synuclein aggregation and toxicity, finding it accelerates fibrillization and enhances pathological features in neuronal models.