Alexander Makarov

This paper introduces a method to infer lipid CCS values from LC-Orbitrap MS data, improving isomer annotation in lipidomics with high precision and accuracy.

This paper introduces a high-resolution multi-pass Astral analyzer mode for TMT proteomics, enabling 35-plex quantification with improved depth and precision.

This paper evaluates a prototype Orbitrap Astral Zoom mass spectrometer for quantitative proteomics, showing improved performance in ion detection and quantitative precision compared to the standard Orbitrap Astral MS.

This study evaluates the Orbitrap Astral MS's sensitivity for single-cell proteomics, showing improved proteome coverage and quantitative accuracy in low-input samples.

The paper evaluates the Orbitrap Astral mass spectrometer for plasma glycoproteome analysis, introducing nGlycoDIA to achieve high sensitivity and throughput.

This paper demonstrates the use of electron-capture charge reduction (ECCR) to deconvolve heterogeneous signals in native mass spectrometry, achieving m/z values above 200,000 for large biopharmaceutical analytes.

The paper introduces hybrid-DIA, a method combining targeted and discovery phosphoproteomics for single spheroids, showing comparable accuracy to existing methods while profiling the global phosphoproteome.

This study evaluates the Astral mass analyzer's performance in single-cell proteomics using DIA, showing improved proteome depth and quantitative precision for ultra-low input samples.

The paper introduces Narrow-window DIA, a fast proteomics method enabling high-throughput and comprehensive proteome analysis with high precision and accuracy.

The paper characterizes an Omnitrap-Orbitrap mass spectrometer with multiple ion activation methods, showing its versatility in peptide and protein analysis.

This paper introduces native ES-IBD for preparing high-purity, ice-free cryo-EM samples, showing structural integrity but limitations in 2D classes and 3D EM density maps.