Pauline J. Kolbeck

This paper investigates how DMSO affects DNA structure and mechanics using single-molecule techniques and simulations, finding that DMSO increases DNA flexibility and compaction up to 50% concentration.

This paper introduces NanoRCS, a method using nanopore sequencing and consensus calling to accurately estimate tumor fractions from cfDNA by analyzing SNVs, CNAs, and fragmentomics.

The paper uses coarse-grained simulations and unsupervised learning to study protein-mediated DNA compaction, finding that protein-protein interactions are critical for forming looped structures observed experimentally.

This study shows HIV integrase compacts viral DNA into biphasic condensates, with the core susceptible to inhibitors and the outer layer resistant.