Extracellular DNASE1L3 dysfunction fuels obesity-driven inflammation and metabolic syndrome
Amandine Ferrière, Anaïs Roubertie, Ekaterina Pisareva, R. Gallo, Purbita Bandopadhyay, Pauline Santa, Anne Garreau, Séverine Loizon, Damien Brisou, Aliki Vasilakou, Aminata Cisse, Maxime Dubois, Blandine Gatta‐Cherifi, Philippe Zizzari, Daniela Cota, , Vanja Sisirak
This study shows that reduced DNASE1L3 activity in obesity leads to increased cfDNA and inflammation, contributing to metabolic syndrome and MASLD, and that restoring DNASE1L3 can mitigate these effects.
bioRxiv · Mar 25, 2026 · PreprintPathology