Purbita Bandopadhyay

This study shows that reduced DNASE1L3 activity in obesity leads to increased cfDNA and inflammation, contributing to metabolic syndrome and MASLD, and that restoring DNASE1L3 can mitigate these effects.

This study identifies PIEZO1 mechanosensing as a key regulator of ligand-specific TLR9 signaling in human pDCs, showing that CpGA induces IFN production via membrane tension and PIEZO1 activation, while CpGB does not.