PARP16 protects against pathological cardiac remodelling by ADP-ribosylation-dependent inhibition of NFAT transcription factor
Sima Zarinfard, Sukanya Raghu, Arathi Bangalore Prabhashankar, Abhishek Chowdhury, Pavithra Jayadevan, Raksha Rajagopal, Anurag Sharma, Amarjeet Shrama, Prasanna Simha Mohan Rao, Utpal Nath, Kumaravel Somasundaram, Michael O. Hottiger, Nagalingam Ravi Sundaresan
This study shows PARP16 reduces cardiac remodelling by inhibiting NFAT transcription through ADP-ribosylation, with implications for heart failure treatment.
bioRxiv · Jul 1, 2026 · PreprintCell Biology