Nagalingam Ravi Sundaresan

This study shows PARP16 reduces cardiac remodelling by inhibiting NFAT transcription through ADP-ribosylation, with implications for heart failure treatment.

This study shows PARP1 deficiency causes aging-related cardiac failure by activating Akt signaling, leading to hypertrophy and fibrosis in mice.

This study identifies SIRT2 as a regulator of stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signaling, showing protective effects in mice.

This study identifies SIRT2 as a regulator of global protein synthesis by modulating Rheb-GTPase activity, showing its potential as a therapeutic target for diseases with increased protein synthesis.

This study shows SIRT2 reduces JEV infection in mice by inhibiting NF-κB and enhancing autophagy, improving survival and reducing viral load.