Evaluating the transcriptional fidelity of cancer models
Da Peng, Rachel Gleyzer, Wen-Hsin Tai, Pavithra Kumar, Qin Bian, Bradley Isaacs, Edroaldo Lummertz da Rocha, Stephanie Cai, Kathleen T. DiNapoli, Franklin W. Huang, Patrick Cahan
The paper evaluates the transcriptional fidelity of cancer models using a machine learning tool called CancerCellNet, finding that genetically engineered mice and tumoroids generally show higher fidelity than other model types.
Genome Medicine · Apr 29, 2021Peer-reviewedCancer Biology