Da Peng

This study shows that inhibiting DDX3 in sarcomas induces a Type I interferon response and reduces metastasis when combined with immunostimulant therapy in mouse models.

The paper investigates how CrebA regulates secretory capacity by analyzing gene expression and DNA binding in Drosophila embryos using scRNA-seq and identifies SPCGs as major targets.

This study shows DFMO inhibits Ewing sarcoma metastasis by inducing ferroptosis through polyamine depletion.

This study shows that the small molecule inhibitor WAY262611 inhibits osteosarcoma metastasis by activating Wnt signaling and inducing osteoblastic differentiation.

OneSC simulates synthetic cells across developmental trajectories using Boolean networks inferred from scRNA-seq data, accurately recapitulating cell state transitions and predicting TF perturbation outcomes.

PACNet enables platform-agnostic comparison of cell fate engineering protocols by analyzing transcriptomic data from multiple studies and identifying best practices and off-target effects.

The paper compares in vitro and in vivo embryogenesis using scRNA-seq data and computational tools to evaluate stem cell differentiation protocols.

The paper evaluates the transcriptional fidelity of cancer models using a machine learning tool called CancerCellNet, finding that genetically engineered mice and tumoroids generally show higher fidelity than other model types.