Author

Pedro Leonardo Carvalho de Lima

Instituto Butantan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:Hi-C· 2 Assay:ChIP-seq· 1 Approach:experimental assay· 1 Research Focus:genome assembly· 1 Research Focus:spatial domain detection· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Júlia Pinheiro Chagas da CunhaiD· 3 shared Natália Karla BelliniiD· 3 shared David da Silva PiresiD· 2 shared Alyssa Rossi BorgesiD· 1 shared Ana Carolina TahiraiD· 1 shared Ana Paula C. A. LimaiD· 1 shared Claudia RabuffoiD· 1 shared Danielle Bruno de CarvalhoiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersGenomics

Júlia Pinheiro Chagas da CunhaORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintSep 26, 2025

First Genome-Wide Centromere Map of Trypanosoma cruzi Reveals Linear and 3D Compartment Boundaries and Spatial Clustering

Natália Karla Bellini, Pedro Gabriel Nachtigall, Pedro Leonardo Carvalho de Lima…·Júlia Pinheiro Chagas da Cunha

The paper generates a high-quality genome assembly and centromere map for T. cruzi using Hi-C and ChIP-seq, revealing structural boundaries and 3D clustering of centromeres.

DOI 10.1101/2025.09.26.678825

Hi-CChIP-seq

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GenomicsmBioPeer-reviewedApr 17, 2025

Hidden origami in Trypanosoma cruzi nuclei highlights its nonrandom 3D genomic organization

Natália Karla Bellini, Pedro Leonardo Carvalho de Lima, David da Silva Pires, Júlia Pinheiro Chagas da Cunha

This study reveals the nonrandom 3D genomic organization of Trypanosoma cruzi nuclei through Hi-C data analysis, showing repetitive DNA and noncoding RNA influence chromatin structure and gene regulation.

7 citations

Hi-Cstatistical model

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Molecular BiologybioRxivPreprintApr 16, 2024

Comprehensive Analysis of Nascent Transcriptome Reveals Diverse Transcriptional Profiles Across the Trypanosoma cruzi Genome Underlining the Regulatory Role of Genome Organization, Chromatin Status, and Cis-Acting Elements

Pedro Leonardo Carvalho de Lima, Leticia de Sousa Lopes, Juliana Nunes Rosón…·Júlia Pinheiro Chagas da Cunha

The paper analyzes nascent transcriptomes of Trypanosoma cruzi to show asymmetric transcriptional abundance and links it to genome organization, chromatin status, and cis-acting elements.

8 citations

whole-genome sequencingstatistical model

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