Author

David da Silva Pires

Instituto ButantanORCID 0000-0002-4662-6469Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:Hi-C· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:genome assembly· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Júlia Pinheiro Chagas da CunhaiD· 2 shared Natália Karla BelliniiD· 2 shared Pedro Leonardo Carvalho de Lima· 2 shared Adriana S. A. PereiraiD· 1 shared Amanda Roberta Revoredo VicentinoiD· 1 shared Ana Paula C. A. LimaiD· 1 shared Antonello MaiiD· 1 shared Arasu GanesaniD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersGenomics

Júlia Pinheiro Chagas da CunhaORCID

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3 papers

Recent·Most cited

First Genome-Wide Centromere Map of Trypanosoma cruzi Reveals Linear and 3D Compartment Boundaries and Spatial Clustering

Natália Karla Bellini, Pedro Gabriel Nachtigall, Pedro Leonardo Carvalho de Lima, Herbert Guimarães de Sousa Silva, David da Silva Pires, Claudia Rabuffo, Danielle Bruno de Carvalho, Yasmin Moraes Feno, Ana Paula C. A. Lima, T. Nicolai Siegel, Júlia Pinheiro Chagas da Cunha

The paper generates a high-quality genome assembly and centromere map for T. cruzi using Hi-C and ChIP-seq, revealing structural boundaries and 3D clustering of centromeres.

bioRxiv · Sep 26, 2025 · PreprintGenomics

Hidden origami in Trypanosoma cruzi nuclei highlights its nonrandom 3D genomic organization

Natália Karla Bellini, Pedro Leonardo Carvalho de Lima, David da Silva Pires, Júlia Pinheiro Chagas da Cunha

This study reveals the nonrandom 3D genomic organization of Trypanosoma cruzi nuclei through Hi-C data analysis, showing repetitive DNA and noncoding RNA influence chromatin structure and gene regulation.

mBio · Apr 17, 2025Peer-reviewedGenomics

Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni

Vitor Coutinho Carneiro, Isabel Caetano de Abreu da Silva, Murilo Sena Amaral, Adriana S. A. Pereira, Gilbert O. Silveira, David da Silva Pires, Sergio Verjovski‐Almeida, Frank J. Dekker, Dante Rotili, Antonello Mai, Eduardo José Lopes Torres, Dina Robaa, Wolfgang Sippl, Raymond John Pierce, María Teresa Borrello, , Marcelo Rosado Fantappíé

This study shows that inhibiting SmLSD1 with MC3935 causes transcriptional changes and structural damage in Schistosoma mansoni, leading to parasite death.

PLoS neglected tropical diseases · Jul 1, 2020Peer-reviewedMolecular Biology