Júlia Pinheiro Chagas da Cunha

The paper identifies phosphorylation sites on proteins associated with the RNA exosome in yeast, showing distinct phosphorylation patterns between nuclear and core subunits that suggest regulatory roles in exosome function.

This study profiles tRNA modifications in different life stages of Trypanosoma cruzi and finds that hydroxywybutosine modification levels regulate metacyclogenesis.

The paper generates a high-quality genome assembly and centromere map for T. cruzi using Hi-C and ChIP-seq, revealing structural boundaries and 3D clustering of centromeres.

This study identifies Maspin as a cytoskeleton-binding protein that modulates cell shape and prevents epithelial-mesenchymal transition by interacting with microtubules and microfilaments.

The paper investigates codon usage bias and its relationship with protein expression in Trypanosoma cruzi by integrating tRNA sequencing and transcriptomic data.

This study identifies phase-specific nuclear proteome changes in Trypanosoma cruzi during the cell cycle, revealing metabolic enzymes' role in nuclear processes.

This study identifies a novel histone H4 variant (H4.V) in Trypanosoma cruzi, showing distinct genomic localization, expression profiles, and chromatin-binding dynamics compared to H2B.V.

This study reveals the nonrandom 3D genomic organization of Trypanosoma cruzi nuclei through Hi-C data analysis, showing repetitive DNA and noncoding RNA influence chromatin structure and gene regulation.

This study uses mass spectrometry to characterize histone PTMs in sugarcane, identifying extensive modifications and distinct patterns across histone variants.

This study investigates how branched-chain amino acids (BCAAs) affect the proteomic profile of Pro-induced differentiation in Trypanosoma cruzi, revealing metabolic changes linked to reduced infectivity.

The paper analyzes nascent transcriptomes of Trypanosoma cruzi to show asymmetric transcriptional abundance and links it to genome organization, chromatin status, and cis-acting elements.

This paper investigates the structure, function, and interactions of selenophosphate synthetase in Trypanosomatidae parasites, showing its role in ER stress response regulation.

The paper profiles Y1 cells treated with FGF-2, revealing epigenetic and transcriptomic changes consistent with oncogene-induced senescence.