Author

Ana Paula C. A. Lima

Universidade Federal do Rio de JaneiroORCID 0000-0003-4631-2694Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1 Assay:Hi-C· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Anthony J. WilkinsoniD· 2 shared James A. BranniganiD· 2 shared Jeremy Charles MottramiD· 2 shared Juliana B. T. CarnielliiD· 2 shared Adam DowleiD· 1 shared Charlotte HughesiD· 1 shared Claudia RabuffoiD· 1 shared Danielle Bruno de CarvalhoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

Anthony J. WilkinsonORCID

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3 papers

Recent·Most cited

Molecular BiologyPLoS PathogensPeer-reviewedMay 13, 2026

Chemical genetics reveals Leishmania KKT2 and CRK9 kinase activity is required for cell cycle progression

Juliana B. T. Carnielli, J.A. Brannigan, Nathaniel G. Jones…·Jeremy Charles Mottram

This study identifies KKT2 and CRK9 as essential kinases for Leishmania cell cycle progression using chemical genetics and CRISPR-Cas9.

6 citationstop 1%

experimental assay

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GenomicsbioRxivPreprintSep 26, 2025

First Genome-Wide Centromere Map of Trypanosoma cruzi Reveals Linear and 3D Compartment Boundaries and Spatial Clustering

Natália Karla Bellini, Pedro Gabriel Nachtigall, Pedro Leonardo Carvalho de Lima…·Júlia Pinheiro Chagas da Cunha

The paper generates a high-quality genome assembly and centromere map for T. cruzi using Hi-C and ChIP-seq, revealing structural boundaries and 3D clustering of centromeres.

DOI 10.1101/2025.09.26.678825

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Cell BiologybioRxivPreprintSep 19, 2025

The mitotic spindle kinase MSK co-ordinates segregation of the nucleus and kinetoplast in Leishmania mexicana

Juliana B. T. Carnielli, Vincent Geoghegan, James A. Brannigan…·Jeremy C. Mottram

This study identifies MSK as a kinase essential for coordinating nucleus and kinetoplast segregation in Leishmania mexicana, showing its role in mitotic spindle function and cell survival.

DOI 10.1101/2025.09.19.677349

experimental assaycell type annotation

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