Tissue-Specific Iron Levels Modulate Lipid Peroxidation and the FLASH Radiotherapy Effect
Nuria Vilaplana‐Lopera, Ji Young Kim, Gilyeong Nam, Iain D. C. Tullis, Salomé Paillas, Jia-Ling Ruan, Pei Ju Lee, Yanyan Jiang, Sohee Park, Tianxu Hou, Ayesha Nasir, Eve Charlesworth, Ellie Walker, Ammar Abu-Halawa, Mark A. Hill, , Eui Jung Moon
This study shows FLASH RT increases lipid peroxidation and ferroptosis in tumors but not normal tissues, and high-iron diets negate FLASH's protective effect in normal tissues.
Cell Death and Disease · Sep 2, 2025Peer-reviewedCancer Biology