Glyceraldehyde-3-phosphate sensing by SOS1 and RAS sustains a self-reinforcing oncogenic metabolic-signaling circuit
Ruixue Xia, Huimin Lei, 乡蝉, Yabin Tang, Peichen Zou, Xu Guo, Jianlin Li, Yuchen Han, Hongzhuan CHEN, Liang Zhu
This study identifies a metabolic-signaling circuit in RAS-mutant cancers driven by GA3P, which enhances SOS1-RAS interaction and sustains oncogenic activity through MAZ-GLUT6 glucose reprogramming.
bioRxiv · Oct 13, 2026 · PreprintCancer Biology