Author

Pengfei Liu

Max Planck Institute for Biology

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Biology Disciplines

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Genetic & Genomic Medicine· 3 Genomics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:database / resource· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:clustering· 1

Frequent Co-Authors

Hongzheng DaiiD· 3 shared Adeline Vanderver· 2 shared Alan H. BeggsiD· 2 shared Alyssa A. Tran· 2 shared Anna Raper· 2 shared Arjun TarakadiD· 2 shared Ashok BalasubramanyamiD· 2 shared Brendan LeeiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Hongzheng DaiORCID

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5 papers

Recent·Most cited

Domain specific phenotypic expansion associated with variants in MACF1

Nikhita Gogate, Angad Jolly, Jill Anne Rosenfeld, Paulina Bahena Carbajal, Diana Carrasco, Jonathan A. Bernstein, Devon E. Bonner, Tiffany Busa, Ingrid Cristian, Precilla D’Souza, Jennifer Friedman, Svetlana Gorokhova, Thomas Haaf, Isabella Herman, Uğur Ufuk Işın, , Shamil R. Sunyaev

The paper identifies domain-specific phenotypic effects of MACF1 variants outside the GAR domain, revealing broader neurodevelopmental and craniofacial anomalies.

Genetics in Medicine · Oct 1, 2026Peer-reviewedGenetic & Genomic Medicine

An AI System for Autonomous Algorithm Evolution in Drug Development

Zhimeng Zhou, Yang Nan, Minjie Mou, Yuntao Qian, Yixiu Liu, Zhengyu Zuo, Hao Yang, Weixian Xu, Bo Li, Wanghao Jiang, Yanlin Ren, Yang Liao, Yimeng Wang, Yingxia Li, Qingxia Yang, , Feng Zhu

DrugEvolve autonomously evolves algorithms across drug development stages, improving performance on benchmark tests and showing generalizability across data modalities.

bioRxiv · Aug 20, 2026 · PreprintPharmacology & Toxicology

Ensilication preserves high-molecular weight native DNA for clinical long-read sequencing

Alexis Ferrasse, Rodrigo Mendez, John E. Gorzynski, Chloe M. Reuter, Jennefer N. Carter, Michael Blas, Undiagnosed Diseases Network, Alyssa A. Tran, Arjun Tarakad, Ashok Balasubramanyam, Brendan Lee, Carlos A. Bacino, Daryl A. Scott, Elaine Seto, Gary D. Clark, , Carlos A. Pardo-Villamizar

This paper demonstrates that ensilication preserves DNA integrity at ambient temperature, enabling diagnostic-quality long-read sequencing without cold-chain infrastructure.

Genome biology · Jun 15, 2026Peer-reviewedGenetic & Genomic Medicine

Lineage-wide evolution of 3D genome organisation and centromeres in brown algae

Pengfei Liu, Rory J. Craig, Elena Avdievich, Fabian B. Haas, Chang Liu, Susana M. Coelho

The paper presents a lineage-wide evolutionary analysis of 3D genome architecture and organization across brown algae, revealing conserved chromosomal features, lineage-specific rearrangements, and long-term co-evolution of centromeres and retrotransposons.

bioRxiv · Dec 10, 2025 · PreprintGenomics

RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental disorder SpADMiSS

Avinash V. Dharmadhikari, Maria Alba Abad, Reza Maroofian, Elena Kondakova, Alejandro D. Iglesias, Bernt Popp, Rami Abou Jamra, Daniel C. Koboldt, Amy Feldman Lewanda, Pengfei Liu, Dana Marafi, Jennifer Ellen Posey, Erin L. Heinzen, David B. Goldstein, Cyril Mignot, , Universitat Autònoma de Barcelona. Departament de Medicina

The paper identifies SPOUT1/CENP-32 as a causative gene for SpADMiSS, linking its dysfunction to mitotic spindle defects and neurodevelopmental disorders.

Nature Communications · Feb 17, 2025Peer-reviewedGenetic & Genomic Medicine