Structural basis for recognition of a gonococcal lipooligosaccharide epitope by monoclonal antibody 2C7 informs vaccine and immunotherapeutic design
Anastasia S. Tsagkarakou, Ferran Nieto‐Fabregat, Alessandro Antonio Masi, Yunqin Zhang, Fei Fan, Jutamas Shaughnessy, Peter A. Rice, Xuefei Huang, Sanjay Ram, Peter T. Beernink, Alba Silipo
This study determines the structural basis for mAb 2C7 recognition of a gonococcal LOS epitope, identifying a minimal tetrasaccharide that retains key binding determinants for vaccine and therapeutic design.
bioRxiv · May 29, 2026 · PreprintMicrobiology