Maëva Dhaynaut

Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer 3MeO4AP

The paper develops an automated radiosynthesis protocol for [11C]3MeO4AP and evaluates its biodistribution and dosimetry in non-human primates.

Radiochemical Synthesis and Evaluation of 3-methyl-4-aminopyridine in Rodents and Non-Human Primates for Imaging Potassium Channels in the CNS

The paper describes the synthesis and evaluation of [11C]3Me4AP, a tracer for imaging Kv1 channels in the CNS, showing lower brain uptake and slower kinetics compared to related tracers.

PET imaging studies to investigate functional expression of mGluR2 using mG2P001

The paper investigates the functional expression of mGluR2 using PET imaging with [11C]mG2P001, showing increased accumulation with pretreatment and validating its use as a biomarker.

Design, synthesis, and characterization of mG2P026 as a high contrast PET imaging ligand for metabotropic glutamate receptor 2

The paper describes the synthesis and characterization of [18F]mG2P026 as a PET ligand for mGluR2, showing improved brain permeability and binding compared to existing compounds.

Synthesis and characterization of 5-(2-fluoro-4-pyridine-7-carboxamide as a PET imaging ligand for metabotropic glutamate receptor 2

The paper develops and characterizes [11C]13, a PET ligand for mGluR2, showing its brain distribution and response to mGluR2 NAMs in rats and nonhuman primates.

Radiochemical synthesis and evaluation in nonhuman primates of 3-methoxy-4-aminopyridine: a novel PET tracer for imaging potassium channels in the CNS

This paper develops and evaluates [11C]3MeO4AP, a PET tracer for imaging potassium channels in the CNS, showing high brain permeability, metabolic stability, and sensitivity to brain injury.

Evaluation of the potassium channel tracer 3F4AP in rhesus macaques

This study evaluates the PET tracer [18F]3F4AP in rhesus macaques for detecting demyelination, showing higher sensitivity than existing tracers and MRI methods.