Nicolas J. Guehl

The paper develops an automated radiosynthesis protocol for [11C]3MeO4AP and evaluates its biodistribution and dosimetry in non-human primates.

This study evaluates two fluorinated gabapentin derivatives for brain PET imaging of 2{delta} receptors in rhesus macaques, showing differential brain uptake and displacement characteristics.

The paper describes the synthesis and evaluation of [11C]3Me4AP, a tracer for imaging Kv1 channels in the CNS, showing lower brain uptake and slower kinetics compared to related tracers.

The paper investigates the functional expression of mGluR2 using PET imaging with [11C]mG2P001, showing increased accumulation with pretreatment and validating its use as a biomarker.

The paper describes the synthesis and characterization of [18F]mG2P026 as a PET ligand for mGluR2, showing improved brain permeability and binding compared to existing compounds.

The paper develops and characterizes [11C]13, a PET ligand for mGluR2, showing its brain distribution and response to mGluR2 NAMs in rats and nonhuman primates.

This paper develops and evaluates [11C]3MeO4AP, a PET tracer for imaging potassium channels in the CNS, showing high brain permeability, metabolic stability, and sensitivity to brain injury.

This study evaluates the PET tracer [18F]3F4AP in rhesus macaques for detecting demyelination, showing higher sensitivity than existing tracers and MRI methods.