Author

Peter Ruben Letsch

University Hospital Schleswig-Holstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Axel Kuenstner· 1 shared Carolin GragolliD· 1 shared Christian FrerkeriD· 1 shared Christoph KnosallaiD· 1 shared Derk FrankiD· 1 shared Elias RawishiD· 1 shared Hauke S. BuschiD· 1 shared Ingo Eitel· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Axel Kuenstner

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1 paper

Recent·Most cited

Sphingolipid-Driven Lipotoxicity Promotes Calcific Aortic Valve Disease Through ER-Stress-NF-κB-EndMT Signaling and Is Therapeutically Targetable Through Serine Palmitoyltransferase Inhibition

Elias Rawish, Timo Rusack, Peter Ruben Letsch, Julica Inderhees, Kristian Haendler, Carolin Gragoll, Jakob Christoph Voran, Michael Schneider, Katharina Kurz, Mohammed Rabiul Hosen, Maren Behrensen, Svenja Denker, Axel Kuenstner, Thorben Sauer, Jorge Duque Escobar, , Christian Frerker

This study identifies ceramide-driven lipotoxicity as a driver of calcific aortic valve disease and shows that SPT inhibition can reverse disease progression in vivo.

bioRxiv · Oct 7, 2026 · PreprintMolecular Biology