Derk Frank

This study identifies ceramide-driven lipotoxicity as a driver of calcific aortic valve disease and shows that SPT inhibition can reverse disease progression in vivo.

This study identifies a cardio-intestinal innate immune circuit driven by tricuspid valve regurgitation that promotes heart failure through IL-6-mediated myocardial fibrosis and dysfunction.

This study identifies Gadlor1 and Gadlor2 as endothelial cell-derived lncRNAs that worsen cardiac remodeling through EV-mediated crosstalk with cardiomyocytes.