Cancer BiologybioRxivPreprint
Selective killing of cancer cells via simultaneous destabilization of mitochondrial iron metabolism and induction of ferroptosis elicited by mitochondrially targeted iron chelator deferasirox
Sukanya B. Jadhav, Cristián Sandoval-Acuña, Yaiza Pacior…·Jaroslav Truksa
This study introduces mitoDFX, a mitochondrially targeted iron chelator that simultaneously depletes iron and induces ferroptosis, showing high selectivity and efficacy against cancer cells.
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