Kristýna Blažková

This paper introduces a method using macrocyclic phage display to identify selective protease substrates, demonstrating its effectiveness with FAP and DPP4.

This study identifies a secreted protease from Bacteroides fragilis that cleaves PAR2, leading to intestinal inflammation and pain in mouse models.

This paper develops polymer-tethered fluorescent probes for tumor-associated protease imaging, showing improved signal and tumor-to-background ratios compared to small molecule probes.

This study introduces mitoDFX, a mitochondrially targeted iron chelator that simultaneously depletes iron and induces ferroptosis, showing high selectivity and efficacy against cancer cells.