Ubiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance
Mahlon A. Collins, Corinna Friedrich, Megan Elcheikhali, Peyton Stewart, Jason Derks, Theresa R. Connors, Kirstin Altig, Alexandra N. Melloni, Aleksandra A. Petelski, Derek H. Oakley, Bradley T. Hyman, Nikolai Slavov
This study identifies proteomic changes in Alzheimer's disease, revealing decreased 20S proteasome levels and altered ubiquitin system enzymes contributing to protein accumulation.
bioRxiv · May 29, 2025 · PreprintNeuroscience