Author

Alexandra N. Melloni

Massachusetts General HospitalORCID 0000-0002-0657-5919Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Bradley T. HymaniD· 4 shared Derek H. OakleyiD· 2 shared Kirstin Altig· 2 shared Rosemary J. JacksoniD· 2 shared Theresa R. ConnorsiD· 2 shared Tsuneo NakajimaiD· 2 shared Alberto Serrano‐PozoiD· 1 shared Aleksandra A. PetelskiiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersNeuroscience

Bradley T. HymanORCID

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4 papers

Recent·Most cited

Lipidated ApoE is found in nanoscale proximity to Aβ aggregates in human Alzheimer brains.

Desmond Owusu Kwarteng, Rosemary J. Jackson, Tsuneo Nakajima, Kirstin Altig, Alexandra N. Melloni, Derek Oakley, Alberto Serrano‐Pozo, Masato Maesako, Bradley T. Hyman

The paper shows lipidated ApoE is closely located to Aβ aggregates in human Alzheimer's brains, suggesting a role in plaque formation.

bioRxiv · Jun 3, 2026 · PreprintNeuroscience

Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation

Noé Quittot, Dhanush Sivasankaran, Dorothea Böken, Yu Chen, Joshua E Chun, Anne E. Wiedmer, Victoria Derosla, M Martins, Forest A Brooks, Georg Meisl, Matthew W. Cotton, Durga G Arumuganainar, Theresa R. Connors, Alexandra N. Melloni, Matthew P. Frosch, , Bradley T. Hyman

The paper identifies rare bioactive tau oligomers in Alzheimer's brain that can induce templated misfolding and fibril formation, distinguishing them from non-bioactive oligomers.

bioRxiv · Sep 24, 2025 · PreprintNeuroscience

Ubiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance

Mahlon A. Collins, Corinna Friedrich, Megan Elcheikhali, Peyton Stewart, Jason Derks, Theresa R. Connors, Kirstin Altig, Alexandra N. Melloni, Aleksandra A. Petelski, Derek H. Oakley, Bradley T. Hyman, Nikolai Slavov

This study identifies proteomic changes in Alzheimer's disease, revealing decreased 20S proteasome levels and altered ubiquitin system enzymes contributing to protein accumulation.

bioRxiv · May 29, 2025 · PreprintNeuroscience

APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease

Rosemary J. Jackson, Megan S. Keiser, Jonah C Meltzer, Dustin P. Fykstra, Steven E. Dierksmeier, Soroush Hajizadeh, Johannes Kreuzer, Robert Tyler Morris, Alexandra N. Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T. Ranum, Ellie M. Carrell, YongHong Chen, Maryam A. Nishtar, , Bradley T. Hyman

This paper shows that APOE2 gene therapy reduces amyloid deposition, neurodegeneration, and microglial activation in an Alzheimer's mouse model with ongoing APOE4 expression.

Molecular Therapy · Mar 18, 2024Peer-reviewedNeuroscience