Mahlon A. Collins

The paper introduces multiDIA, a proteomics method that improves sequence coverage and scalability in neurodegenerative disease studies by combining multiple proteases and data-independent acquisition.

The paper investigates how genotype-by-environment interactions influence the ubiquitin-proteasome system activity in yeast by analyzing genetic effects across different environments and substrates.

This study identifies proteomic changes in Alzheimer's disease, revealing decreased 20S proteasome levels and altered ubiquitin system enzymes contributing to protein accumulation.

The paper identifies 15 genomic loci influencing proteasome activity in yeast using single-cell measurements and CRISPR-based engineering, revealing substrate-specific genetic effects.

The paper identifies genetic variants affecting UPS activity in yeast by mapping loci influencing N-degron recognition and ubiquitination.

This study identifies RBM45's role in forming nuclear inclusions during stress and in neurodegenerative diseases, linking it to nuclear stress bodies and disease-specific pathology.